What is a primary concern when using supplemental oxygen long-term?

When using supplemental oxygen long-term, oxygen toxicity becomes a primary concern due to the potential for oxygen concentrations to reach levels that can cause harm to the lungs and other organs. Oxygen is vital for cellular metabolism, but in excessive amounts, particularly at higher pressures or concentrations, it can produce harmful reactive oxygen species. This oxidative stress can damage lung tissues, leading to conditions such as atelectasis or pneumonitis, and may exacerbate pre-existing lung diseases. It is particularly critical in patients with chronic respiratory illnesses, as their lungs may already be compromised, and additional stress from high concentrations of oxygen could worsen their condition. Therefore, careful monitoring and regulation of oxygen therapy are essential to minimize the risks associated with long-term use.