To minimize the risk of ROP, the American Academy of Pediatrics recommends keeping PaO2 below what level?

The American Academy of Pediatrics recommends keeping the partial pressure of oxygen in arterial blood (PaO2) below 80 mm Hg to minimize the risk of retinopathy of prematurity (ROP) in premature infants. ROP is a serious eye condition that can lead to vision loss and is influenced by high levels of oxygen, which can cause abnormal blood vessel growth in the retina. Maintaining oxygen levels within appropriate limits is crucial for the developing eyes of these infants.

When the PaO2 is overly elevated, it can contribute to oxidative stress and disrupt normal vascular development in the retina, leading to ROP. Therefore, controlling oxygen therapy and ensuring that the PaO2 does not exceed 80 mm Hg helps in reducing the incidence of this complication while still providing adequate oxygenation to support the overall health of the infant.